From Howard CR, Howard FM, Weitzman ML, Acetominophen Analgesia in Neonatal Circumcision: The Effect on Pain, PEDIATRICS, Vol 93 No. 4, pp.641-646. April 1994.: "The observed deterioration in postoperative feeding behavior has been documented by other investigators. (29) Infants feed less frequently and are less available for interaction after circumcision. Subdued, less interactive behavior has been documented frequently and are less available for interaction after circumcision. (6,11,30) In this study, acetominophen seemed to have no effect on this deterioration. Because most hospital discharges occurred 7 to 10 hours after circumcision, the data are inadequate to assess the duration of the effects on feeding. Neonatal circumcision are often performed on the day of discharge with many neonates leaving the hospital 3 to 6 hours postoperatively. Thus the observed deterioration in ablity to breast-feed my potentially contribute to breast feeding failure. Furthermore some neonates in this study required formula supplementation because of maternal frustration with attempts at breast-feeding. or because the neonate was judged unable to breast-feed postoperatively. This finding is disconcerting because early formula supplemenation is associated with decreased breast-feeding duration. (30,31) Because, the vast majority of male infants in the United States undergo unanesthetised circumcision, this preliminary observation deserves further study." Ref: 6. Marshal, ER, Stratton WC, Moore JA, boxerman SB, Circumcision I: effects upon newborn behavior. Infant Behav Dev. 1980;3:1-14 11 Dixon S, Snyder J, Holve R, Bromberger P. Behavioral Aspects of circumcision with and without anesthesia. J Dev Behav Pediatr 1984;5:246-250 29. Marshall Re, Porter FL Rogers AG Moore J, Anderson B Boxerman SB, Circumcinsion II: effects upon mother-infant interaction. Early Human Development 1982;7:367-374 30. Emde R, Harmon R, Metcalf D. et al. Stress and Neontal Sleep. Psychosum Med.`1971;33:491-497 31. Loughlin,hh, Clapp-Channing NE, Gelbach SH, Pollard JC, McCutcheon TM. Early Termination of breast-feeding identiying those at risk. PEDIATRICS, 1988;81:365-371