Histology and physiology of tissue expansion

The Journal of Dermatologic Surgery and Oncology, Volume 19, Issue 12: Pages 1074-1078, December 1993.

Johnson TM, Lowe L, Brown MD, Sullivan MJ, Nelson BR.

Department of Dermatology,
University of Michigan,
Ann Arbor 48109.

BACKGROUND: Tissue expansion is a concept based on the skin's natural ability to stretch in response to an underlying force.

OBJECTIVE: The purpose of this article is to review the histological and physiological changes that occur within the soft tissue and underlying structures during tissue expansion.

METHODS: An extensive search of the literature reviewing these changes is summarized herein.

RESULTS: Conventional tissue expansion may result in epidermal hypertrophy, decreased dermal, muscle, and adipose thickness, and bone resorption. A vascular capsule and angiogenesis provides a highly vascular flap and improves flap viability. Few soft tissue changes occur during rapid tissue expansion. The ability of the skin to increase in surface area during conventional tissue expansion is primarily because of biological tissue creep. Rapid expansion may result from mechanical tissue creep.

CONCLUSION: Many soft tissue changes occur during tissue expansion. Most of these changes return to the pre-expansion state over time following discontinuation of the expansion process.

Publication Types:

Review
Review, Tutorial

PMID: 8282904 [PubMed - indexed for MEDLINE]

Citation:

Johnson TM, Lowe L, Brown MD, et al. Histology and physiology of tissue expansion. J Dermatol Surg Oncol 1993;19(12):1074-8.

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