Conservative Treatment of Phimosis in Boys

British Journal of Urology, Volume 78: Pages 786-788, November 1996.


¹ Department of Plastic and Reconstructive Surgery
² Department of Pediatric Urology, University Children's Hospital, Belgrade, Yugoslavia.


Objective: To further test the application of topical steroids in boys referred to a paediatric surgical practice with pathological,non-retractable foreskins diagnosed as phimosis.

Patients and Methods: This prospective study comprised two groups of 20 boys each (mean age 4.1 years, range 3-6) diagnosed as having phimosis, twice daily, a topical steroid (0.05% betamethasone cream) was applied on the narrowed preputial skin in the first group and a neutral cream (Vaseline) in the second (control) group. Patients were treated for 4 weeks and the retractability of the foreskin and any side-effectsassessed.

Results: Good retraction of the foreskin was achieved in 19 patients with betamethasone cream and the response was unsatisfactory in 16 patients from the control groups; these 16 boys and one 6-year old boy treated with betamethasone were circumcized. There were no side-effects or problems after the application of eithercream.

Conclusion: Treatment with 0.05% betamethasone cream is a simple and safe method for the treatment of phimosis in boys older than 3 years. An early operation is necessary in cases of genuine phimosis when 1 month of treatment with topical steroids has failed. We strongly support the saying, `The fortunate foreskin of an infant boy will usually be left well alone by everyone butits owner'.

Keywords Phimosis, conservative treatment, topicalsteroids, children.


The suspicion of phimosis in boys is more frequent than its real occurrence: the diagnosis of phimosis is often used for different non-obstructive conditions of the foreskin, e. g. preputial adhesions or a tight prepuce1. Typically, the foreskin is unretractable at the time of birth but this condition generally resolves in the first 4 years of life2. The incidence of phimosis decreases from 8 to 1% in adolescence3 and surgery has been the only treatment for boys aged >3 years with a diagnosed phimosis4,5. Recently, topical steroids were introduced as an alternative treatment for phimosis6 and the present study examined the effectiveness of betamethasone ina prospective trial.

Patients and methods

Between October 1994 and October 1995, 40 boys (mean age 4.1 years, range 3-6 were included in a prospective study of the efficacy of 0.05% betamethasone cream in the treatment of phimosis. Phimosis was defined as an unretractable foreskin with no adhesions but with a circular band of constriction making complete retractionimpossible. (Fig. 1)

Two groups of 20 boys each were prospectively assessed in a double-blind, ramdomised trial: the first group of patients was treated with betamethasonecream applied on the narrowed


Fig. 1 A typical phimosis of the foreskin before treatment.

preputial skin and the second (control) placebo group treated with neutral cream (Vaseline). The parents were instructed to apply a thin layer of cream on the child's foreskin, from the coronal groove to the meatus, twice daily for 4 weeks. They were asked not to attempt to retract the foreskin during the first two weeks of treatment, but after this period the narrowed foreskin becomes soft and elastic and parents were encouraged to then retract theforeskin gently and gradually.

The patients were considered cured if the foreskin was fully retractable at 4 weeks, and the outcome was also determined 1, 3, and 6 months after treatment. The protocol was not repeated and those patients not cured after 4 weeks of therapy were referred for surgery. All the patients were examined at 1, 14, and 28 days after the start of treatment and the cortisol levels assessed using a blood spot test (Soft Touch, Boehringer, Mannheim, Germany) 1 hafter the morning application of cream.


The results were assessed after a mean follow-up of 10.5 months (range 6-18); no local or systemic side-effects occurred after treatment. Good retraction of the foreskin was achieved in 19 patients treated with betamethasone cream (Fig. 2) but the response wasunsatisfactory in 16 patients from the control group


Figure 2. A fully retractable foreskin obtained after treatment with 0.05% betamethasone cream for 4weeks.

(P<0.001); these 16 boys and one 6 year old boy from the treated group were circumcized. A histological examination by one pathologist confirmed lichen sclerosis et atrophicus in four excised foreskins, non-specific chronic inflammatory infiltrate in 11 and normalskin in two.

The mean (sd) amount of cream applied per patient per treatment was 9.5 (3.2)g. giving a mean (sd) 47.5 (16) mg of active substance applied topically per patient per treatment or 1.53 mg. daily. The mean (sd) morning bloodspot cortisol levels were not significantly different between the two groups, at 271.1 (39.13.) nmol/T. in those treated with betamethasone and 295 (41.1) nmof/L in the control group (P=0.958).


Congenital physiological phimosis regresses spontaneously in the first years of life but unfortunately this resolution is difficult to predict7,8. Although the symptoms in the present patients were ambigious and generally mild, the main reason for presentation of such patients to a paediatric surgical practice is the concern of their parents9. The Christian orthodox and most other European cultures prefer to leave the foreskin intact and thus circumcision is not accepted easily unless unavoidable. Therefore, in the present study, the parents were usually pleased when a conservative treatment with topical steroid was proposed.

The histological assessment of the excised foreskins from circumcised patients showed findings similar to those reported previously10,11 and the present results using topical steroids agree with those published previously6,12-14. There were no local or systemic side-effects after treatment with topical steroid; 0.05% betamethasone cream applied to the foreskin involves <0.1% of the total body area and thus such effects are very unlikely.

In summary, treatment with a topical steroid is a simple, safe and painless method for the treatment of phimosis in boys older than three years. We strongly support the saying, "the fortunate foreskin of an infant boy will usually be left alone by everyone but its owner.8


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Z. Golubovic, MD, Assistant Professor of Pediatric Surgery.
D. Milanovic, MD, PhD, Assistant Professor of Pediatric Urology.
V. Vukadinovic, MD, Pediatric Urologist.
I. Rakic, MD, Junior Registrar.
S. Perovic, MD, PhD, Senior Consultant, Professor of Pediatric Urology and Pediatric Surgery, Head of Department.
Correspondence: Assistant Professor Dr. Dragan Milanovic, Marsala Tolbuhina 86/16, 11000 Belgrade, Yugoslavia.


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